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Product Name: |
Methyl propionate |
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CAS: |
554-12-1 |
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MF: |
C4H8O2 |
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MW: |
88.11 |
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EINECS: |
209-060-4 |
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Mol File: |
554-12-1.mol |
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Melting point |
-88 °C |
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Boiling point |
79 °C(lit.) |
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density |
0.915 g/mL at 25 °C(lit.) |
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vapor density |
3 (vs air) |
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vapor pressure |
40 mm Hg ( 11 °C) |
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refractive index |
n20/D 1.376(lit.) |
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FEMA |
2742 | METHYL PROPIONATE |
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Fp |
43 °F |
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storage temp. |
Flammables area |
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solubility |
H2O: soluble16 parts |
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form |
Liquid |
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color |
Clear colorless |
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explosive limit |
2.5-13%(V) |
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Water Solubility |
5 g/100 mL at 20 ºC |
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JECFA Number |
141 |
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Merck |
14,6112 |
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BRN |
1737628 |
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Stability: |
Stable. Highly flammable. Incompatible with strong oxidizing agents, acids, bases. Readily forms explosive mixtures with air. Moisture sensitive. |
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CAS DataBase Reference |
554-12-1(CAS DataBase Reference) |
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NIST Chemistry Reference |
Propanoic acid, methyl ester(554-12-1) |
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EPA Substance Registry System |
Methyl propionate (554-12-1) |
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Hazard Codes |
F,Xn |
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Risk Statements |
11-20-2017/11/20 |
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Safety Statements |
16-24-29-33 |
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RIDADR |
UN 1248 3/PG 2 |
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WGK Germany |
1 |
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RTECS |
UF5970000 |
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Autoignition Temperature |
876 °F |
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TSCA |
Yes |
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HS Code |
2915 50 00 |
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HazardClass |
3 |
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PackingGroup |
II |
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Hazardous Substances Data |
554-12-1(Hazardous Substances Data) |
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Toxicity |
LD50 orally in Rabbit: 5000 mg/kg |
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Uses |
Methyl propionate is
used as a solvent for cellulose nitrate and lacquers, and as a raw material
for the production of paints, varnishes and other chemicals such as methyl
methacrylate. |
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Uses |
In organic synthesis. |
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Preparation |
Methyl propionate can be prepared by esterification of propionic acid with methanol. Industrially, it is prepared by the reaction of ethylene with carbon monoxide and methanol in the presence of nickel carbonyl. |
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Production Methods |
Methyl propionate is produced by the direct esterification of propionic acid with methanol in the presence of concentrated sulfuric acid . |
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Production Methods |
Methyl propionate is produced by the direct esterification of propionic acid with methanol in the presence of concentrated sulfuric acid. |
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Aroma threshold values |
Detection: 100 ppb to 8.8 ppm |
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General Description |
A clear colorless liquid. Flash point 28°F. Density about the same as water. Vapors heavier than air. May irritate skin, eyes, and mucous membranes. Used for flavoring and as a solvent. |
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Air & Water Reactions |
Highly flammable. Soluble in water. |
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Reactivity Profile |
Methyl propionate reacts with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction with caustic solutions. Flammable hydrogen is generated with alkali metals and hydrides. |
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Hazard |
Flammable, dangerous fire risk, explosivelimits in air 2.5–13%. |
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Health Hazard |
May cause toxic effects if inhaled or absorbed through skin. Inhalation or contact with material may irritate or burn skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution. |
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Fire Hazard |
HIGHLY FLAMMABLE: Will be easily ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water. |
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Safety Profile |
Moderately toxic by ingestion. Mildly toxic by inhalation. A skin irritant. A very dangerous fire hazard when exposed to heat, flame, or oxidizers. Explosive in the form of vapor when exposed to heat or flame. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes. |
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Chemical Synthesis |
By direct esterification of the acid with methanol in the presence of concentrated H2SO4 |
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Potential Exposure |
Used as a solvent; and in making paints, lacquers, and varnishes. Also used in flavorings and fragrances |
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Shipping |
UN1248 Methyl propionate, Hazard Class: 3; Labels: 3-Flammable liquid. |
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Purification Methods |
Wash the ester with saturated aqueous NaCl, then dry it with Na2CO3 and distil it from P2O5. (This removes any free acid and alcohol.) It has also been dried with anhydrous CuSO4. [Beilstein 2 IV 104.] |
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Incompatibilities |
May form explosive mixture with air. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Keep away from heat and moisture. |
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Raw materials |
Propionic acid |
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Preparation Products |
Metalaxyl-->Pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate)-->Ramipril-->N-Benzyl-4-piperidone-->1-BENZYL-4-HYDROXY-4-(3-TRIFLUOROTOLYL)PIPERIDINOL-->Procymidone-->Methyl 1-benzyl-4-oxo-3-piperidine-carboxylate hydrochloride-->Benalaxyl-->efficient polymer catalyst for acrylation-synthesis and characterigation of polyamide containing supernucleophilic reagent-->CYANOACRYLIC ACID METHYL ESTER-->Ethyl 2-chloropropionate-->hydrazide-->4-Amino-6-chloropyrimidine-->CARBETAMIDE-->BORONAL-->Methyl 3-methylthiopropionate-->DICLOFOP-METHYL-->CIS-1,2-DIMETHYL-CYCLOPROPANEDICARBOXYLIC ACID DIMETHYL ESTER-->Disperse Red 127 |
